- Obesity and Metabolism
- Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status
-
Tae Hoon Lee, Won Seon Jeon, Ki Joong Han, Shin Yeoung Lee, Nam Hee Kim, Hyun Beom Chae, Choel Min Jang, Kyung Mo Yoo, Hae Jung Park, Min Kyung Lee, Se Eun Park, Hyung Geun Oh, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
-
Endocrinol Metab. 2015;30(2):185-194. Published online June 30, 2015
-
DOI: https://doi.org/10.3803/EnM.2015.30.2.185
-
-
4,660
View
-
34
Download
-
16
Web of Science
-
15
Crossref
-
Abstract
PDFPubReader
- Background
Metabolic health is an emerging concept that is highly correlated with various metabolic complications, and adipocytokines have been causally linked to a wide range of metabolic diseases. Thus, this study compared serum adipocytokine levels according to metabolic health and obesity status. MethodsFour hundred and fifty-six nondiabetic subjects (mean age, 40.5 years) were categorized into four groups according to metabolic health and obesity status: metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUHNO), and metabolically unhealthy obese (MUHO). Being metabolically healthy was defined as the presence of fewer than two of the following five metabolic abnormalities: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostatic model assessment of insulin resistance index. Obesity status was assessed using body mass index (BMI), with obesity defined as a BMI higher than 25 kg/m2. Levels of serum interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNF-α), and adipocyte fatty acid binding protein (A-FABP) were also evaluated. ResultsOf the 456 subjects, 247 (54.2%) were in the MHNO group, 66 (14.5%) were in the MHO group, 66 (14.5%) were in the MUHNO group, and 77 (16.9%) were in the MUHO group. There were no significant differences in IL-6 or MCP-1 levels among the groups, but levels of TNF-α and A-FABP were significantly higher in the MUHNO group compared to the MHNO group. ConclusionHigh TNF-α and A-FABP levels are significantly associated with metabolically unhealthiness in nonobese Korean individuals.
-
Citations
Citations to this article as recorded by
- Differences in the levels of inflammatory markers between metabolically healthy obese and other obesity phenotypes in adults: A systematic review and meta-analysis
Zhouli Su, Ljupcho Efremov, Rafael Mikolajczyk Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(2): 251. CrossRef - Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
Eman Y. Khairy, Azza Saad The Journal of Physiological Sciences.2023;[Epub] CrossRef - Pattern of Adiponectin, Osteocalcin, Irisin, FGF-21, and MCP-1 According to the Body Size Phenotype: Could They Be Markers of Metabolic Health in Mexican-Mestizo Middle-Aged Women?
Lourdes Balcázar-Hernandez, Lourdes Basurto, Leticia Manuel-Apolinar, Sara Vega-García, Norma Basurto-Acevedo, Carlos Martínez-Murillo, Rosalinda Sánchez-Arenas Metabolites.2021; 11(11): 771. CrossRef - Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity
Tenzin D. Dagpo, Christopher J. Nolan, Viviane Delghingaro-Augusto Cells.2020; 9(7): 1596. CrossRef - Poor Vitamin D Status in Active Pulmonary Tuberculosis Patients and Its Correlation with Leptin and TNF-α
Qiuzhen WANG, Aiguo MA, Tianlin GAO, Yufeng LIU, Lisheng REN, Lei HAN, Boyang WEI, Qian LIU, Chunjiang DONG, Yuze MU, Duo LI, Frans J KOK, Evert G SCHOUTEN Journal of Nutritional Science and Vitaminology.2019; 65(5): 390. CrossRef - Metabolic Health—The Role of Adipo-Myokines
Christine Graf, Nina Ferrari International Journal of Molecular Sciences.2019; 20(24): 6159. CrossRef - Does the Metabolically Healthy Obese Phenotype Protect Adults with Class III Obesity from Biochemical Alterations Related to Bone Metabolism?
Ligiane Marques Loureiro, Suzane Lessa, Rodrigo Mendes, Sílvia Pereira, Carlos José Saboya, Andrea Ramalho Nutrients.2019; 11(9): 2125. CrossRef - Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
Eun-Jung Rhee Diabetes & Metabolism Journal.2018; 42(1): 19. CrossRef - Association between Serum Dipeptidyl Peptidase-4 Concentration and Obesity-related Factors in Health Screen Examinees
Ji Yeon Lee, Byoung Kuk Jang, Min Kyung Song, Hye Soon Kim, Mi-Kyung Kim Journal of Obesity & Metabolic Syndrome.2017; 26(3): 188. CrossRef - Kofaktoren und Komorbiditäten bei Necrobiosis lipoidica – Analyse der deutschen DRG‐Daten von 2012
Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277. CrossRef - The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee BMC Pulmonary Medicine.2016;[Epub] CrossRef - Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012
Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt‐Berge, Joachim Dissemond JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2016; 14(3): 277. CrossRef - Response: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
Eun-Jung Rhee Endocrinology and Metabolism.2015; 30(3): 416. CrossRef - Letter: Comparison of Serum Adipocytokine Levels according to Metabolic Health and Obesity Status (Endocrinol Metab2015;30:185-94, Tae Hoon Lee et al.)
Mikyung Kim Endocrinology and Metabolism.2015; 30(3): 414. CrossRef - Adipokine Profiles and Metabolic Health
Seung-Hwan Lee Endocrinology and Metabolism.2015; 30(2): 175. CrossRef
|